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Molecular pathway of estrogen receptor (ER) action. Typically, estrogen binds to the ligand-binding domain of receptors in the nucleus, which causes a conformational change. Estrogen-responsive elements (ERE) mediate genomic effects. RE, response element; TF, transcription factor; GF, growth factor; GF-R, growth factor receptor; CoA, co-activator; CoR, co-repressor; MAPK, mictogen-activated protein kinase; PI3K, phophoinositide 3-kinase; Src, proto-oncogene tyrosine-protein kinase; AP-1, activating protein-1; Sp-1, stimulating protein-1. Adapted from Nie et al.
Measurement parameters utilized to determine the esophageal motor function. (A) Esophagogastric junction (EGJ). (B) Esophageal body. EGJ-CI, esophagogastric junction-contractile integral; IRP, integrated relaxation pressure; LES, lower esophageal sphincter.
High-resolution manometry test swallows and maneuvers. (A) Supine 5 mL liquid; (B) upright 5 mL liquid; (C) viscous (apple sauce); (D) solid (graham cracker); (E) multiple rapid swallow; and (F) rapid drink challenge. Integrated relaxation pressure (IRP) and distal contractile integral (DCI) were 11 mmHg and 1760 mmHg·cm·sec (A), 8 mmHg and 1950 mmHg·cm·sec (B), 7 mmHg and 1600 mmHg·cm·sec (C), 10 mmHg and 1400 mmHg·cm·sec (D), 4 mmHg and 4600 mmHg·cm·sec (E), and 3 mmHg and 0 mmHg·cm·sec (F), respectively. Figure used with permission from the Esophageal Center at Northwestern.
Our diagnostic algorithm of defecation disorders using a colonic transit study. DD, defecation disorders; DRE, digital rectal examination; NTC, normal transit constipation; STC, slow transit constipation; RS, rectosigmoid colon.
Statistical maps showing voxel-mirrored homotopic connectivity (VMHC) differences between irritable bowel syndrome (IBS) and healthy controls (HCs;
P < 0.05, corrected with Alphasim). IBS patients showed much higher VMHC in superior occipital gyrus, middle occipital gyrus, precuneus, posterior cingulate gyrus, and angular gyrus (red), while lower in supplementary motor area (blue). The color bar indicates the T-value from t test between groups.
J Neurogastroenterol Motil 2021; 27(3): 307~443 Total PDF
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July 2021 Volume 27 Issue 3
Tae Hee Lee Institute for Digestive Research, Soonchunhyang University Seoul Hospital, Seoul, Korea
Yu Kyung Cho Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary’s hospital, Seoul, Korea
Jung Ho Park Departments of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul, Korea
Uday C Ghoshal Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Kewin T H Siah Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore
The aim of the Journal is to foster and promote research activities on the area of the motor, sensory and functional disorders of gastrointestinal tract. The Journal provides researchers with accessible rooms for publication of their research results in the field of neuroga- stroenterology and motility.
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